Custom Peptides
Cayman Chemical S-5-FluorowIlardIIn 10mg
An inhibitor of the eIF4E-eIF4G protein-protein interaction (IC50 13.5 UM) reduces mRNA translation without inducing apoptosis in L-132 cells at 12.5 UM decreases intracellular and extracellular SARS-COV titers and the percentage of cells expressing spike glycoprotein in SARS-COV-infected L-132 cells at 6 UM
Cayman Chemical DIphenylterazIn 10mg
An inhibitor of the K-Ras-SOS1 protein-protein interaction (IC50 5 nM) selectively disrupts the protein-protein interaction between K-RasG12C or K-RasG12D with SOS1 over SOS2 and it is selective over 321 kinases in a panel at 10 UM but does inhibit PLK4 BMPR2 and LRRK2 activity by 50
Cayman Chemical AMPR22trIfluoroACTAte sal 10mg
An AT1 receptor antagonist (IC50 3.3 nM) inhibits angiotensin II-induced pressor responses in conscious normotensive rats decreases mean arterial pressure in conscious spontaneously hypertensive rats at 1.082 Umol/kg improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg in the drinking water decreases disease severity and NF-KB and AP-1 activation in a mouse model of LPS-induced acute lung injury at 10 mg/kg
Cayman Chemical Nethyl Perfluoroctnsulfon 10mg
A pentacyclic triterpenoid inhibits glycogen phosphorylase and cathepsin L but not cathepsin B (IC50s 19 6.5 and 250 UM respectively) inhibits entry of bovine parainfluenza virus 3 into MDBK cells at 20-50 UM inhibits the proliferation of MCF-7 cells (IC50 18.6 Ug/ml)
Cayman Chemical ChloraznIlhydrochlorIde 10mg
A prodrug form of acetaminophen reduces acetic acid-induced writhing in mice and LPS-induced pyresis in rats at 200 and 600 mg/kg respectively induces hepatotoxicity decreases hepatic GSH SOD and GPX levels increases hepatic MDA and nitrotyrosine levels and increases mortality in mice at 1200 mg/kg
Cayman Chemical DebIo 0123hydrochlorIde 10mg
A flavonoid glycoside with lipid-lowering activity reduces sodium oleate-induced increases in triglyceride levels in HepG2 cells at 30 UM
Cayman Chemical BMAP 28bovIntrIfluoroac 10mg
A flavonoid with antioxidant and anticancer activities scavenges superoxide anions in a cell-free assay at 100 UM decreases EGFR and phosphorylated EGFR levels in and reduces viability of PC-9 and H1975 NSCLC cells at 25 and 50 UM decreases intratumoral levels of EGFR and phosphorylated EGFR and reduces tumor growth in an H1975 mouse xenograft model at 1 mg/kg
Cayman Chemical Glycyza ualns Fsc Glabl 10mg
A phenylurea herbicide inhibits the androgenic effect of dihydrotestosterone in MDA-kb2 breast cancer cells (IC20 1.74 UM in a reporter assay) inhibits testosterone-induced growth of the seminal vesicles ventral prostate and levator ani and bulbocavernosus muscles in castrated rats at 100 mg/kg post-emergent application to carrots controls the growth of the weeds redroot pigweed and lambsquarters
Cayman Chemical UNC8153trIfluoROCTAte sal 10mg
A non-nucleoside inhibitor of HCV NS5B reduces viral infectivity in cells expressing wild-type HCV 1b NS5B but not mutant NS5Bs selectively inhibits replication of HCV genotypes 1a and 1b over genotype 2a in Huh7-Lunet cells (EC50s 13.8 0.8 and 21900 nM respectively)
Cayman Chemical 1 2DIheptadecnoylsnglycer 10mg
An inhibitor of wild-type and mutant Bcr-Abl (IC50s 15 and 9-400 nM respectively) selective for wild-type and mutant Bcr-Abl over Src and LYN (IC50s 5000 nM for both) inhibits Bcr-Abl autophosphorylation and cell proliferation in Ba/F3 cells expressing wild-type or mutant Bcr-Abl (IC50s 7-155 and 13-51 nM respectively) reduces midbrain Bcr-Abl autophosphorylation amyloid-B levels and neuronal loss as well as improves autophagosome clearance and reverses cognitive deficits in the Tg2576 transgenic mouse model of Alzheimers disease at 1 mg/kg reduces serum creatine levels renal profibrotic gene expression and tubulointerstitial damage as well as increases survival in a rat model of 5/6 nephrectomy-induced chronic kidney disease
Cayman Chemical EnsIfentrIn 10mg
A flavonol glycoside with antibacterial and antioxidant activities active against methicillin-sensitive and -resistant S. aureus as well as Enterococcus in disc diffusion assays at 250 Ug/ml scavenges ABTS and DPPH radicals in cell-free assays
Cayman Chemical 8BromoInosIn5OtrIphosph 600ug
A colorimetric peroxidase substrate enzymatic oxidation produces a radical cation followed by a diimine product that can be quantified by colorimetric detection at 652 and 450 nm respectively as a measure of peroxidase activity has commonly been used as a substrate for HRP in ELISA and immunohistochemical applications
Cayman Chemical LK6L9trIfluoroACTAte salt 10mg
An inhibitor of survivin inhibits survivin dimerization in a SEAP assay using DU145 prostate cancer cells expressing surviving induces survivin degradation in C4-2 and PC3 cells in a proteasome-dependent manner cytotoxic to C4-2 and PC3 cells (IC50s 3.1 and 4.8 UM respectively) reduces tumor growth in a PC3 prostate cancer mouse xenograft model at 100 mg/kg
Cayman Chemical LevobupIvacaInd9hydrochlo 10mg
A building block has been used in the synthesis of MC3R agonists and antimicrobial peptidomimetics
Cayman Chemical BRC4wtrIfluoroacetAT salt 10mg
An antiviral nucleoside analog inhibits cytopathogenicity induced by HIV or MSV in MT-4 cells (EC50s 0.36 and 15 UM respectively)